Rheumatoid Arthritis

How are Comparators Changing for Biologics in Rheumatoid Arthritis (RA)?

While biologics are emerging as the standard of care for rheumatoid arthritis (RA), they continue to be compared to methotrexate frequently in health technology assessments (HTAs). We examined comparators used by HTA agencies for RA drugs, both tumor necrosis factor (TNF) drugs and disease-modifying, anti-rheumatic drugs (DMARDs), and compared each drug’s HTA decision to its European label. We also assessed the change in comparator categories for RA drugs over time.

Regulatory Restrictions on Biologic Rheumatoid Arthritis Drugs

A drug’s market share is dependent on several external factors, one of which is the drug’s health technology assessment (HTA). We analyzed HTA decisions from NICE, HAS, IQWiG, HIS, and SMC for rheumatoid arthritis (RA) drugs, specifically examining the subpopulations established by the HTA agencies through restrictions against the European label, and noting whether these restrictions changed over time.